α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1

Abnormal α-Synuclein (α-SYN) aggregates are the pathological hallmarks of Parkinson’s disease (PD), which may affect dopamine (DA) neuron function and DA metabolism. Monoamine oxidase A (MAOA) is an enzyme located on the outer mitochondrial membrane that catalyzes the oxidative deamination of DA. Bo...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Jia, Congcong, Cheng, Cheng, Li, Tianbai, Chen, Xi, Yang, Yuting, Liu, Xinyao, Li, Song, Le, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010665/
https://ncbi.nlm.nih.gov/pubmed/33815093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.653379
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