Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

Receptor interacting protein kinase-2 (RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain (NOD) cell signaling, a pathway implicated in numerous chronic inflammatory conditions. Herein, a pyrido[2,3-d]pyrimidin-7-one based class of RIPK2 ki...

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Udgivet i:Eur J Med Chem
Main Authors: Nikhar, Sameer, Siokas, Ioannis, Schlicher, Lisa, Lee, Seungheon, Gyrd-Hansen, Mads, Degterev, Alexei, Cuny, Gregory D.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009825/
https://ncbi.nlm.nih.gov/pubmed/33601309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2021.113252
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