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Deep neural networks identify sequence context features predictive of transcription factor binding

Transcription factors (TFs) bind DNA by recognizing specific sequence motifs, typically of length 6–12bp. A motif can occur many thousands of times in the human genome, but only a subset of those sites are actually bound. Here we present a machine learning framework leveraging existing convolutional...

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Pubblicato in:Nat Mach Intell
Autori principali: Zheng, An, Lamkin, Michael, Zhao, Hanqing, Wu, Cynthia, Su, Hao, Gymrek, Melissa
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009085/
https://ncbi.nlm.nih.gov/pubmed/33796819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42256-020-00282-y
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