Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth of tumors but often leads to the emergence of slowly dividing persister cells, which constitute a reservoir for the selection of drug-resistant clones. In BRAF(V600E) melanomas, RAF and MEK inhibitors effic...

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Publicado no:Cell Syst
Main Authors: Gerosa, Luca, Chidley, Christopher, Fröhlich, Fabian, Sanchez, Gabriela, Lim, Sang Kyun, Muhlich, Jeremy, Chen, Jia-Yun, Vallabhaneni, Sreeram, Baker, Gregory J., Schapiro, Denis, Atanasova, Mariya I., Chylek, Lily A., Shi, Tujin, Yi, Lian, Nicora, Carrie D., Claas, Allison, Ng, Thomas S.C., Kohler, Rainer H., Lauffenburger, Douglas A., Weissleder, Ralph, Miller, Miles A., Qian, Wei-Jun, Wiley, H. Steven, Sorger, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009031/
https://ncbi.nlm.nih.gov/pubmed/33113355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.10.002
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