Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth of tumors but often leads to the emergence of slowly dividing persister cells, which constitute a reservoir for the selection of drug-resistant clones. In BRAF(V600E) melanomas, RAF and MEK inhibitors effic...

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Dades bibliogràfiques
Publicat a:Cell Syst
Autors principals: Gerosa, Luca, Chidley, Christopher, Fröhlich, Fabian, Sanchez, Gabriela, Lim, Sang Kyun, Muhlich, Jeremy, Chen, Jia-Yun, Vallabhaneni, Sreeram, Baker, Gregory J., Schapiro, Denis, Atanasova, Mariya I., Chylek, Lily A., Shi, Tujin, Yi, Lian, Nicora, Carrie D., Claas, Allison, Ng, Thomas S.C., Kohler, Rainer H., Lauffenburger, Douglas A., Weissleder, Ralph, Miller, Miles A., Qian, Wei-Jun, Wiley, H. Steven, Sorger, Peter K.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009031/
https://ncbi.nlm.nih.gov/pubmed/33113355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.10.002
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