Enhanced Delivery of Plasmid DNA to Skeletal Muscle Cells using a DLC8-Binding Peptide and ASSLNIA-Modified PAMAM Dendrimer

Skeletal muscle is ideally suited and highly desirable as a target for therapeutic gene delivery because of its abundance, high vascularization, and high levels of protein expression. However, efficient gene delivery to skeletal muscle remains a current challenge. Besides the major obstacle of cell-...

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Vydáno v:Mol Pharm
Hlavní autoři: Jativa, Samuel D., Thapar, Neelanshu, Broyles, David, Dikici, Emre, Daftarian, Pirouz, Jiménez, Joaquín J., Daunert, Sylvia, Deo, Sapna K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008946/
https://ncbi.nlm.nih.gov/pubmed/30951315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b01313
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