Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by macrophage infiltration, and the mechanisms regulating macrophage-mediated inflammation remai...

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Udgivet i:J Exp Med
Main Authors: Davis, Frank M., Tsoi, Lam C., Melvin, William J., denDekker, Aaron, Wasikowski, Rachael, Joshi, Amrita D., Wolf, Sonya, Obi, Andrea T., Billi, Allison C., Xing, Xianying, Audu, Christopher, Moore, Bethany B., Kunkel, Steven L., Daugherty, Alan, Lu, Hong S., Gudjonsson, Johann E., Gallagher, Katherine A.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008365/
https://ncbi.nlm.nih.gov/pubmed/33779682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201839
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