Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents

Gain at chromosome 17q21 in neuroblastoma is associated with a poor prognosis, independent of MYCN amplification status. Several potential proto-oncogenes have been identified in this region, one of them—insulin-like growth-factor-2 mRNA binding protein (IGF2BP1)—is expressed at high levels in stage...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Biegel, Jason M., Dhamdhere, Mayura, Gao, Shuang, Gowda, Chethana P., Kawasawa, Yuka Imamura, Spiegelman, Vladimir S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008117/
https://ncbi.nlm.nih.gov/pubmed/33796454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.608816
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