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Absence of Pannexin 1 Stabilizes Hippocampal Excitability After Intracerebral Treatment With Aβ (1-42) and Prevents LTP Deficits in Middle-Aged Mice

Beta-amyloid protein [Aβ(1-42)] plays an important role in the disease progress and pathophysiology of Alzheimer's disease (AD). Membrane properties and neuronal excitability are altered in the hippocampus of transgenic AD mouse models that overexpress amyloid precursor protein. Although gap ju...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Südkamp, Nicolina, Shchyglo, Olena, Manahan-Vaughan, Denise
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007872/
https://ncbi.nlm.nih.gov/pubmed/33796018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.591735
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