Absence of Pannexin 1 Stabilizes Hippocampal Excitability After Intracerebral Treatment With Aβ (1-42) and Prevents LTP Deficits in Middle-Aged Mice

Beta-amyloid protein [Aβ(1-42)] plays an important role in the disease progress and pathophysiology of Alzheimer's disease (AD). Membrane properties and neuronal excitability are altered in the hippocampus of transgenic AD mouse models that overexpress amyloid precursor protein. Although gap ju...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Aging Neurosci
Egile Nagusiak: Südkamp, Nicolina, Shchyglo, Olena, Manahan-Vaughan, Denise
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2021
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007872/
https://ncbi.nlm.nih.gov/pubmed/33796018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.591735
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