The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

Metabolic enzymes and metabolites display non-metabolic functions in immune cell signalling that modulate immune attack ability. However, whether and how a tumour’s metabolic remodelling contributes to its immune resistance remain to be clarified. Here we perform a functional screen of metabolic gen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Shang, Man, Yang, Huijie, Yang, Ran, Chen, Tao, Fu, Yuan, Li, Yeyi, Fang, Xianlong, Zhang, Kangjian, Zhang, Jianju, Li, Hui, Cao, Xueping, Gu, Jinfa, Xiao, Jianwen, Zhang, Qi, Liu, Xinyuan, Yu, Qiujing, Wang, Ting
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007798/
https://ncbi.nlm.nih.gov/pubmed/33782411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22173-5
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