Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation

Cancer-associated fibroblasts (CAFs) contribute to malignant progression and chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, little is known about the underlying mechanism. In this study, we investigated the potential role and mechanisms of activating transcription factor 4 (ATF...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Wei, Lusheng, Lin, Qing, Lu, Yanan, Li, Guolin, Huang, Leyi, Fu, Zhiqiang, Chen, Rufu, Zhou, Quanbo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007632/
https://ncbi.nlm.nih.gov/pubmed/33782384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03574-2
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