Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer

Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gem...

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Publicat a:Cell Death Dis
Autors principals: Wei, Lusheng, Ye, Huilin, Li, Guolin, Lu, Yuanting, Zhou, Quanbo, Zheng, Shangyou, Lin, Qing, Liu, Yimin, Li, Zhihua, Chen, Rufu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194073/
https://ncbi.nlm.nih.gov/pubmed/30337520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1104-x
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