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Cardiac expression of HMOX1 and PGF in sickle cell mice and haem-treated wild type mice dominates organ expression profiles via Nrf2 (Nfe2l2)

Haemolysis is a major feature of sickle cell disease (SCD) that contributes to organ damage. It is well established that haem, a product of haemolysis, induces expression of the enzyme that degrades it, haem oxygenase-1 (HMOX1). We have also shown that haem induces expression of placental growth fac...

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Bibliografski detalji
Izdano u:Br J Haematol
Glavni autori: Gbotosho, Oluwabukola T., Ghosh, Samit, Kapetanaki, Maria G., Lin, Yu, Weidert, Frances, Bullock, Grant C., Ofori-Acquah, Solomon F., Kato, Gregory J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007233/
https://ncbi.nlm.nih.gov/pubmed/31389006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.16129
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