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Free heme regulates Placenta Growth Factor through NRF2-antioxidant response signaling.

Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating levels of PlGF have been associated in experimental animals and in patients with sickle cell disease with echocardiographic markers of pulmonary hyperten...

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Publicado en:Free Radic Biol Med
Autores principales: Kapetanaki, Maria G, Gbotosho, Oluwabukola T, Sharma, Deva, Weidert, Frances, Ofori-Acquah, Solomon F, Kato, Gregory J
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848791/
https://ncbi.nlm.nih.gov/pubmed/31408727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.08.009
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