Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice

Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme, proinflammatory cytokines, and cardiac hypertrophy are co-existing features of SCD, no mechanistic links between these features have been demons...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Gbotosho, Oluwabukola T., Kapetanaki, Maria G., Ghosh, Samit, Villanueva, Flordeliza S., Ofori-Acquah, Solomon F., Kato, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473032/
https://ncbi.nlm.nih.gov/pubmed/32973791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01910
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