Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice

Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme, proinflammatory cytokines, and cardiac hypertrophy are co-existing features of SCD, no mechanistic links between these features have been demons...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Gbotosho, Oluwabukola T., Kapetanaki, Maria G., Ghosh, Samit, Villanueva, Flordeliza S., Ofori-Acquah, Solomon F., Kato, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473032/
https://ncbi.nlm.nih.gov/pubmed/32973791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01910
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