An Entry to Enantioenriched 3,3-Disubstituted Phthalides through Asymmetric Phase-Transfer-Catalyzed γ-Alkylation

[Image: see text] A novel asymmetric phase-transfer-catalyzed γ-alkylation of phthalide 3-carboxylic esters has been developed, giving access to 3,3-disubstituted phthalide derivatives, which present a chiral quaternary γ-carbon in good to excellent yields and good enantioselectivities (74–88% ee)....

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Publicat a:J Org Chem
Autors principals: Sicignano, Marina, Schettini, Rosaria, Pierri, Giovanni, Marino, Maria Leda, Izzo, Irene, De Riccardis, Francesco, Bernardi, Luca, Sala, Giorgio Della
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007094/
https://ncbi.nlm.nih.gov/pubmed/32403930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c00880
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