Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction

Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1–7). However, whether melatonin attenuates small-intestine injury along with the precise underlying mechanism remain to be elucidated. To investig...

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Udgivet i:Front Immunol
Main Authors: Xu, Siqi, Li, Lulan, Wu, Jie, An, Sheng, Fang, Haihong, Han, Yunyang, Huang, Qiaobing, Chen, Zhongqing, Zeng, Zhenhua
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006917/
https://ncbi.nlm.nih.gov/pubmed/33790896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.625627
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