Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells

BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic islets in early T1D, which may be secondary to viral infections. However, not all patients harb...

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Bibliografiska uppgifter
I publikationen:Auto Immun Highlights
Huvudupphovsmän: Coomans de Brachène, Alexandra, Castela, Angela, Musuaya, Anyïshai E., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2021
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005246/
https://ncbi.nlm.nih.gov/pubmed/33773604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13317-021-00148-2
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