Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules’ loading and spatial arrangement. Here, the impact of increasing the drug load from one to three on the properties...

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Vydáno v:Pharmaceutics
Hlavní autoři: Ding, Haozhong, Xu, Tianqi, Zhang, Jie, Tolmachev, Vladimir, Oroujeni, Maryam, Orlova, Anna, Gräslund, Torbjörn, Vorobyeva, Anzhelika
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005000/
https://ncbi.nlm.nih.gov/pubmed/33806887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13030430
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