Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody–DM1 Drug Conjugates

Affibody molecules are small affinity-engineered scaffold proteins which can be engineered to bind to desired targets. The therapeutic potential of using an affibody molecule targeting HER2, fused to an albumin-binding domain (ABD) and conjugated with the cytotoxic maytansine derivate MC-DM1 (AffiDC...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Ding, Haozhong, Altai, Mohamed, Rinne, Sara S., Vorobyeva, Anzhelika, Tolmachev, Vladimir, Gräslund, Torbjörn, Orlova, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721809/
https://ncbi.nlm.nih.gov/pubmed/31416167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081168
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