Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer’s Achilles’ Heel

SIMPLE SUMMARY: Cancer onset and progression lead to a high rate of DNA damage, due to replicative and metabolic stress. To survive in this dangerous condition, cancer cells switch the DNA repair machinery from faithful systems to error-prone pathways, strongly increasing the mutational rate that, i...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Caracciolo, Daniele, Riillo, Caterina, Di Martino, Maria Teresa, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2021
Ämnen:
Review
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8003480/
https://ncbi.nlm.nih.gov/pubmed/33808562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13061392
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