Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction

Medically important flaviviruses cause diverse disease pathologies and collectively are responsible for a major global disease burden. A contributing factor to pathogenesis is secreted flavivirus non-structural protein 1 (NS1). Despite demonstrated protection by anti-NS1 antibodies against lethal fl...

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Udgivet i:Science
Main Authors: Biering, Scott B., Akey, David L., Wong, Marcus P., Brown, W. Clay, Lo, Nicholas T.N., Puerta-Guardo, Henry, de Sousa, Francielle Tramontini Gomes, Wang, Chunling, Konwerski, Jamie R., Espinosa, Diego A., Bockhaus, Nicholas J., Glasner, Dustin R., Li, Jeffrey, Blanc, Sophie F., Juan, Evan Y., Elledge, Stephen J., Mina, Michael J., Beatty, P. Robert, Smith, Janet L., Harris, Eva
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000976/
https://ncbi.nlm.nih.gov/pubmed/33414220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc0476
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