Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation

Arthropod-borne flaviviruses cause life-threatening diseases associated with endothelial hyperpermeability and vascular leak. We recently found that vascular leak can be triggered by dengue virus (DENV) non-structural protein 1 (NS1) via the disruption of the endothelial glycocalyx-like layer (EGL)....

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Wang, Chunling, Puerta-Guardo, Henry, Biering, Scott B., Glasner, Dustin R., Tran, Edwina B., Patana, Mark, Gomberg, Trent A., Malvar, Carmel, Lo, Nicholas T. N., Espinosa, Diego A., Harris, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687192/
https://ncbi.nlm.nih.gov/pubmed/31356638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007938
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