Mechanistic basis for ubiquitin modulation of a protein energy landscape

Ubiquitin is a common posttranslational modification canonically associated with targeting proteins to the 26S proteasome for degradation and also plays a role in numerous other nondegradative cellular processes. Ubiquitination at certain sites destabilizes the substrate protein, with consequences f...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Carroll, Emma C., Latorraca, Naomi R., Lindner, Johanna M., Maguire, Brendan C., Pelton, Jeffrey G., Marqusee, Susan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000280/
https://ncbi.nlm.nih.gov/pubmed/33723075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025126118
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