ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP

DNA end resection is a critical step in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). However, the mechanisms governing the extent of resection at DSB sites undergoing homology-directed repair remain unclear. Here, we show that, upon DSB induction, the key resectio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Han, Jinhua, Wan, Li, Jiang, Guixing, Cao, Liping, Xia, Feiyu, Tian, Tian, Zhu, Xiaomei, Wu, Mingjie, Huen, Michael S. Y., Wang, Yi, Liu, Ting, Huang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000100/
https://ncbi.nlm.nih.gov/pubmed/33723063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022600118
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