Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase

The effect of variations in the expression of cytochrome P450 reductase (CPR or POR) is determined in mice with decreased POR expression to identify potential vulnerabilities in people with low POR expression. There is an age-dependent appearance of increasing vacuolization in the proximal tubules o...

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Dades bibliogràfiques
Publicat a:Toxicol Sci
Autors principals: Ding, Liang, Li, Lei, Liu, Senyan, Bao, Xiaochen, Dickman, Kathleen G, Sell, Stewart S, Mei, Changlin, Zhang, Qing-Yu, Gu, Jun, Ding, Xinxin
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Molecular, Biochemical and Systems Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000068/
https://ncbi.nlm.nih.gov/pubmed/31693140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz225
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