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Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase

The effect of variations in the expression of cytochrome P450 reductase (CPR or POR) is determined in mice with decreased POR expression to identify potential vulnerabilities in people with low POR expression. There is an age-dependent appearance of increasing vacuolization in the proximal tubules o...

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Publicado en:Toxicol Sci
Main Authors: Ding, Liang, Li, Lei, Liu, Senyan, Bao, Xiaochen, Dickman, Kathleen G, Sell, Stewart S, Mei, Changlin, Zhang, Qing-Yu, Gu, Jun, Ding, Xinxin
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000068/
https://ncbi.nlm.nih.gov/pubmed/31693140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz225
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