Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

[Image: see text] Targeting G-quadruplex structures is currently viewed as a promising anticancer strategy. Searching for potent and selective G-quadruplex binders, here we describe a small series of new monohydrazone derivatives designed as analogues of a lead which was proved to stabilize G-quadru...

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Argitaratua izan da:J Med Chem
Egile Nagusiak: Amato, Jussara, Miglietta, Giulia, Morigi, Rita, Iaccarino, Nunzia, Locatelli, Alessandra, Leoni, Alberto, Novellino, Ettore, Pagano, Bruno, Capranico, Giovanni, Randazzo, Antonio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2020
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997572/
https://ncbi.nlm.nih.gov/pubmed/32142285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01866
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