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HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?
This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases...
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| Vydáno v: | Chem Commun (Camb) |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6234227/ https://ncbi.nlm.nih.gov/pubmed/30079419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc03614d |
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