SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase–p53–Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo

Gene-directed enzyme–prodrug therapy (GDEPT) is a promising approach for cancer therapy, but it suffers from poor targeted delivery in vivo. Polyethylenimine (PEI) is a cationic polymer efficient in delivering negatively charged nucleic acids across cell membranes; however, it is highly toxic in viv...

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Vydáno v:ACS Appl Mater Interfaces
Hlavní autoři: Sukumar, Uday K., Rajendran, Jagadesh Chandra Bose, Gambhir, Sanjiv S., Massoud, Tarik F., Paulmurugan, Ramasamy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997290/
https://ncbi.nlm.nih.gov/pubmed/32048820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsami.9b20071
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