The herpesvirus accessory protein γ(1)34.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I

RIG-I and MDA5 are cytoplasmic RNA sensors that mediate cell intrinsic immunity against viral pathogens. While it has been well-established that RIG-I and MDA5 recognize RNA viruses, their interactive network with DNA viruses, including herpes simplex virus 1 (HSV-1), remains less clear. Using a com...

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Udgivet i:PLoS Pathog
Main Authors: Liu, Xing, Ma, Yijie, Voss, Kathleen, van Gent, Michiel, Chan, Ying Kai, Gack, Michaela U., Gale, Michael, He, Bin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7996975/
https://ncbi.nlm.nih.gov/pubmed/33770145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009446
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