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Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT(1A) Serotonin Receptor Antagonists
We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT(1A) and 5-HT(2A) receptors. Molecular docking of all investigated compounds revealed subnanomolar estimates of 5-HT(1A)R K(i) for three ligands and...
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| Publicado no: | Pharmaceuticals (Basel) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7996328/ https://ncbi.nlm.nih.gov/pubmed/33668396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14030179 |
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