Reformulating a Pharmacophore for 5-HT(2A) Serotonin Receptor Antagonists

Several pharmacophore models have been proposed for 5-HT(2A) serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine. Although specified distances might vary, the models are relatively similar...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Younkin, Jason, Gaitonde, Supriya A., Ellaithy, Amr, Vekariya, Rakesh, Baki, Lia, Moreno, José L., Shah, Sneha, Drossopoulos, Peter, Hideshima, Kelsey S., Eltit, Jose Miguel, González-Maeso, Javier, Logothetis, Diomedes E., Dukat, Malgorzata, Glennon, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333931/
https://ncbi.nlm.nih.gov/pubmed/27385190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00162
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