BOK controls apoptosis by Ca(2+) transfer through ER-mitochondrial contact sites

Calcium transfer from the endoplasmic reticulum (ER) to mitochondria is a critical contributor to apoptosis. B cell lymphoma 2 (BCL-2) ovarian killer (BOK) localizes to the ER and binds the inositol 1,4,5-trisphosophate receptor (IP3R). Here, we show that BOK is necessary for baseline mitochondrial...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Carpio, Marcos A., Means, Robert E., Brill, Allison L., Sainz, Alva, Ehrlich, Barbara E., Katz, Samuel G.
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995216/
https://ncbi.nlm.nih.gov/pubmed/33691099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108827
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