PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer cell death in response to therapeutic agents. In several instances, oxidative stress and the onset of endoplasmic reticulum (ER) stress occur together; yet, the molec...

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Detalhes bibliográficos
Main Authors: Verfaillie, T, Rubio, N, Garg, A D, Bultynck, G, Rizzuto, R, Decuypere, J-P, Piette, J, Linehan, C, Gupta, S, Samali, A, Agostinis, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469056/
https://ncbi.nlm.nih.gov/pubmed/22705852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.74
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