Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell lines, PDXs, and patients with acute myeloid leukemia (AML) harboring an IDH mutation displayed an enhanced mitoch...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Stuani, Lucille, Sabatier, Marie, Saland, Estelle, Cognet, Guillaume, Poupin, Nathalie, Bosc, Claudie, Castelli, Florence A., Gales, Lara, Turtoi, Evgenia, Montersino, Camille, Farge, Thomas, Boet, Emeline, Broin, Nicolas, Larrue, Clément, Baran, Natalia, Cissé, Madi Y., Conti, Marc, Loric, Sylvain, Kaoma, Tony, Hucteau, Alexis, Zavoriti, Aliki, Sahal, Ambrine, Mouchel, Pierre-Luc, Gotanègre, Mathilde, Cassan, Cédric, Fernando, Laurent, Wang, Feng, Hosseini, Mohsen, Chu-Van, Emeline, Le Cam, Laurent, Carroll, Martin, Selak, Mary A., Vey, Norbert, Castellano, Rémy, Fenaille, François, Turtoi, Andrei, Cazals, Guillaume, Bories, Pierre, Gibon, Yves, Nicolay, Brandon, Ronseaux, Sébastien, Marszalek, Joseph R., Takahashi, Koichi, DiNardo, Courtney D., Konopleva, Marina, Pancaldi, Véra, Collette, Yves, Bellvert, Floriant, Jourdan, Fabien, Linares, Laetitia K., Récher, Christian, Portais, Jean-Charles, Sarry, Jean-Emmanuel
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995203/
https://ncbi.nlm.nih.gov/pubmed/33760042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200924
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki