FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer

RNASET2 (Ribonuclease T2) functions as a tumor suppressor in preventing ovarian tumorigenesis. However, the mechanisms underlying the regulation of RNASET2 protein are completely unknown. Here we identified the F-box protein FBXO6, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein)...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Ji, Mei, Zhao, Zhao, Li, Yue, Xu, Penglin, Shi, Jia, Li, Zhe, Wang, Kaige, Huang, Xiaotian, Liu, Bin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994844/
https://ncbi.nlm.nih.gov/pubmed/33767133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03580-4
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