TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination

OBJECTIVES: FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such as matrix metalloproteinases, are modified with N-glycans and play important roles in the developm...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Ann Rheum Dis
Main Authors: Wang, Gangliang, Chen, Shuai, Xie, Ziang, Shen, Shuying, Xu, Wenbin, Chen, Wenxiang, Li, Xiang, Wu, Yizheng, Li, Liangping, Liu, Bin, Ding, Xianjun, Qin, An, Fan, Shunwu
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2020
Teme:
Osteoarthritis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7392491/
https://ncbi.nlm.nih.gov/pubmed/32409323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2019-216911
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