Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment

Transmembrane serine protease (TMPRSS2) plays an oncogenic role in prostate cancer as the fusion gene with ERG, and has also been demonstrated to be essential for the cellular entry of severe acute respiratory syndrome coronaviruses (SARS-CoV). Thus, targeting TMPRSS2 is a promising strategy for the...

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Bibliografski detalji
Izdano u:Am J Cancer Res
Glavni autori: Chen, Yeh, Huang, Wei-Chien, Yang, Chia-Shin, Cheng, Fang-Ju, Chiu, Yi-Fang, Chen, Hsiao-Fan, Huynh, Thanh Kieu, Huang, Chih-Feng, Chen, Chia-Hung, Wang, Hsueh-Chun, Hung, Mien-Chie
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2021
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994159/
https://ncbi.nlm.nih.gov/pubmed/33791156
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