Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment

Transmembrane serine protease (TMPRSS2) plays an oncogenic role in prostate cancer as the fusion gene with ERG, and has also been demonstrated to be essential for the cellular entry of severe acute respiratory syndrome coronaviruses (SARS-CoV). Thus, targeting TMPRSS2 is a promising strategy for the...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Chen, Yeh, Huang, Wei-Chien, Yang, Chia-Shin, Cheng, Fang-Ju, Chiu, Yi-Fang, Chen, Hsiao-Fan, Huynh, Thanh Kieu, Huang, Chih-Feng, Chen, Chia-Hung, Wang, Hsueh-Chun, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994159/
https://ncbi.nlm.nih.gov/pubmed/33791156
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