CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice

As a major pathological hallmark of Alzheimer’s disease (AD), amyloid-β (Aβ) is regarded as a causative factor for cognitive impairment. Extensive studies have found Aβ induces a series of pathophysiological responses, finally leading to memory loss in AD. Our previous results demonstrated that cyst...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Chen, Fang, Fang, Shunchang, Du, Yifeng, Ghosh, Arijit, Reed, Miranda N., Long, Yan, Suppiramaniam, Vishnu, Tang, Susu, Hong, Hao
Format: Artigo
Language:Inglês
Published: Impact Journals 2021
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993729/
https://ncbi.nlm.nih.gov/pubmed/33591941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202501
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