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Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect

A new series of quinoline derivatives of combretastatin A-4 have been designed, synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds showed significant antiproliferative activities, among them, 12c exhibited the most potent inhibitory activity against different ca...

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Publicat a:J Enzyme Inhib Med Chem
Autors principals: Ibrahim, Tarek S., Hawwas, Mohamed M., Malebari, Azizah M., Taher, Ehab S., Omar, Abdelsattar M., Neamatallah, Thikryat, Abdel-Samii, Zakaria K., Safo, Martin K., Elshaier, Yaseen A. M. M.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993375/
https://ncbi.nlm.nih.gov/pubmed/33730937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1899168
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