Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models

BACKGROUND: Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), have a dismal prognosis, with less than 2% surviving 5 years postdiagnosis. The majority of DIPGs and all DMGs harbor mutations altering the epigenetic regulatory histone tail (H3 K27M). Investigations a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Vitanza, Nicholas A, Biery, Matt C, Myers, Carrie, Ferguson, Eric, Zheng, Ye, Girard, Emily J, Przystal, Justyna M, Park, Giulia, Noll, Alyssa, Pakiam, Fiona, Winter, Conrad A, Morris, Shelli M, Sarthy, Jay, Cole, Bonnie L, Leary, Sarah E S, Crane, Courtney, Lieberman, Nicole A P, Mueller, Sabine, Nazarian, Javad, Gottardo, Raphael, Brusniak, Mi-Youn, Mhyre, Andrew J, Olson, James M
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992886/
https://ncbi.nlm.nih.gov/pubmed/33130903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa249
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares