HGG-24. PRECLINICAL EFFICACY OF THE BRAIN PENETRANT CYCLIN-DEPENDENT KINASE INHIBITOR ZOTIRACICLIB IN PEDIATRIC DIFFUSE MIDLINE GLIOMAS

Children diagnosed with diffuse midline gliomas (DMG), including diffuse intrinsic pontine glioma (DIPG), have extremely poor outcomes with a median overall survival of 9–12 months from initial diagnosis. Standard-of-care is limited to focal radiation therapy, given the paucity of effective targeted...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Mueller, Timothy, Yadavilli, Sridevi, Laternser, Sandra, Cianciolo, Chiara, Przystal, Justyna, Bonner, Erin, Biery, Matt C, Vitanza, Nicholas A, Grotzer, Michael, Mueller, Sabine, Nazarian, Javad
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
High Grade Gliomas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168210/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.088
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