DDRE-12. HETEROGENOUS RESPONSE OF IDH-MUTANT AND IDH-WT GLIOMA TO NAMPT INHIBITION

BACKGROUND: NAD+ is required for cell metabolism and DNA repair. It is generated from nicotinic acid (NA) by NAPRT and from Nicotinamide (NAM) by NAMPT. D2HG in IDH-mutant tumors methylates and inactivates NAPRT, increasing dependence on NAMPT. Toxic side effects of NAMPT inhibition can be prevented...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Rahman, Masum, Hirte, Renee, Olson, Ian, Mansour, Moustafa, Ikram, Samar, MunozCasabella, Amanda, Sutiwisesak, Rujapope, Carlstrom, Lucas, Warrington, Arthur, Rajani, Karishma, Sarkaria, Jann, Burns, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
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Supplement Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992232/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.034
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