PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

In view of upcoming clinical trials, quantitative molecular markers accessible in peripheral blood are of critical importance as prognostic or pharmacodynamic markers in genetic neurodegenerative diseases such as Spinocerebellar Ataxia Type 3 (SCA3), in particular for signaling target engagement. In...

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Библиографические подробности
Опубликовано в: :J Neurol
Главные авторы: Gonsior, Kathrin, Kaucher, Gabriele Anna, Pelz, Patrik, Schumann, Dorothea, Gansel, Melanie, Kuhs, Sandra, Klockgether, Thomas, Forlani, Sylvie, Durr, Alexandra, Hauser, Stefan, Rattay, Tim W., Synofzik, Matthis, Hengel, Holger, Schöls, Ludger, Rieß, Olaf H., Hübener-Schmid, Jeannette
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2020
Предметы:
Original Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990753/
https://ncbi.nlm.nih.gov/pubmed/33106888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00415-020-10274-y
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