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AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation

BACKGROUND: S‐adenosylmethionine decarboxylase proenzyme (AMD1) is a key enzyme involved in the synthesis of spermine (SPM) and spermidine (SPD), which are associated with multifarious cellular processes. It is also found to be an oncogene in multiple cancers and a potential target for tumor therapy...

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Detalhes bibliográficos
Publicado no:Clin Transl Med
Main Authors: Bian, Xinyu, Shi, Dongmin, Xing, Kailin, Zhou, Hongxin, Lu, Lili, Yu, Dahai, Wu, Weizhong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7989706/
https://ncbi.nlm.nih.gov/pubmed/33783988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.352
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