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Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs

Pegylated arginine deiminase (ADI-PEG20) results in the depletion of arginine with the production of isomolar amounts of citrulline. This citrulline has the potential to be utilized by the citrulline recycling pathway regenerating arginine and sustaining tissue arginine availability. The goal of thi...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Mohammad, Mahmoud A., Didelija, Inka C., Stoll, Barbara, Nguyen, Trung C., Marini, Juan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988784/
https://ncbi.nlm.nih.gov/pubmed/33427052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00472.2020
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