SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis

SOX17 has been implicated in arterial specification and the maintenance of hematopoietic stem cells (HSCs) in the murine embryo. However, knowledge about molecular pathways and stage-specific effects of SOX17 in humans remains limited. Here, using SOX17-knockout and SOX17-inducible human pluripotent...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Jung, Ho Sun, Uenishi, Gene, Park, Mi Ae, Liu, Peng, Suknuntha, Kran, Raymond, Matthew, Choi, Yoon Jung, Thomson, James A., Ong, Irene M., Slukvin, Igor I.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988717/
https://ncbi.nlm.nih.gov/pubmed/33596423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108758
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