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Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy
High tumor mutational burden (TMB) is associated with response to checkpoint blockade in several cancers. We identify pathogenic germline variants associated with increased TMB (GVITMB). GVITMB were found in 7 genes using a pan-cancer approach (APC, FANCL, SLC25A13, ERCC3, MSH6, PMS2, and TP53) and...
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| izdano v: | iScience |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7988326/ https://ncbi.nlm.nih.gov/pubmed/33786423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102248 |
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