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Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy

High tumor mutational burden (TMB) is associated with response to checkpoint blockade in several cancers. We identify pathogenic germline variants associated with increased TMB (GVITMB). GVITMB were found in 7 genes using a pan-cancer approach (APC, FANCL, SLC25A13, ERCC3, MSH6, PMS2, and TP53) and...

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Библиографические подробности
Опубликовано в: :iScience
Главные авторы: Chatrath, Ajay, Ratan, Aakrosh, Dutta, Anindya
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988326/
https://ncbi.nlm.nih.gov/pubmed/33786423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102248
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